Linker Information
General Information of This Linker
| Linker ID |
LIN0NOJQJ
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| Linker Name |
MC-Radiation-responsive linker
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| Linker Type |
Radiation-responsive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C19H26N3O4+
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| Isosmiles |
O=C(C=C1)N(CCCCCC(NCCC[N+]2=CC=C(CO)C=C2)=O)C1=O
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| InChI |
InChI=1S/C19H25N3O4/c23-15-16-8-13-21(14-9-16)11-4-10-20-17(24)5-2-1-3-12-22-18(25)6-7-19(22)26/h6-9,13-14,23H,1-5,10-12,15H2/p+1
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| InChIKey |
MNKFYMMTTUZKOU-UHFFFAOYSA-O
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| Pharmaceutical Properties |
Molecule Weight
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360.434
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Polar area
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90.59
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Complexity
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608.5070861
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xlogp Value
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0.4581
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Heavy Count
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26
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Rot Bonds
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11
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Hbond acc
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4
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Hbond Donor
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2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
nAPC-ADC [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
575.8 nM
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High FAP expression (+++) | ||
| Method Description |
the half-maximal inhibitory concentration (IC50) of NAPC-ADC against 4T1-FAP cells
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| In Vitro Model | Malignant neoplasms of the mouse mammary gland | 4T1-FAP cells | CVCL_0125 | ||