Linker Information
General Information of This Linker
| Linker ID |
LIN0NNNNA
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| Linker Name |
WO2024043319A1 Linker 17
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H39N5O9S2
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)CCOCCN2C(C(SC3=CC=CC=C3)C(SC4=CC=CC=C4)C2=O)=O
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| InChI |
InChI=1S/C36H39N5O9S2/c42-28(37-21-29(43)38-22-30(44)40-27(34(47)39-23-31(45)46)20-24-10-4-1-5-11-24)16-18-50-19-17-41-35(48)32(51-25-12-6-2-7-13-25)33(36(41)49)52-26-14-8-3-9-15-26/h1-15,27,32-33H,16-23H2,(H,37,42)(H,38,43)(H,39,47)(H,40,44)(H,45,46)/t27-,32?,33?/m0/s1
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| InChIKey |
ILHKVWQFALSSOG-BECFNDGMSA-N
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| Pharmaceutical Properties |
Molecule Weight
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749.868
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Polar area
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200.31
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Complexity
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1572.30591
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xlogp Value
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1.2444
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Heavy Count
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52
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Rot Bonds
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20
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Hbond acc
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10
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 17 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.04 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||