Linker Information
General Information of This Linker
| Linker ID |
LIN0NMZEG
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| Linker Name |
Linker of ADC2-38
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H50N8O15
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| Isosmiles |
O=C([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CC(N[C@H](O2)[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@H]2CO)=O)NCC(NCC(N[C@@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C37H50N8O15/c1-20(47)41-32-34(57)33(56)24(19-46)60-37(32)44-26(49)15-23(42-25(48)10-6-3-7-13-45-29(52)11-12-30(45)53)36(59)39-16-27(50)38-17-28(51)43-22(35(58)40-18-31(54)55)14-21-8-4-2-5-9-21/h2,4-5,8-9,11-12,22-24,32-34,37,46,56-57H,3,6-7,10,13-19H2,1H3,(H,38,50)(H,39,59)(H,40,58)(H,41,47)(H,42,48)(H,43,51)(H,44,49)(H,54,55)/t22-,23+,24+,32+,33+,34+,37+/m0/s1
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| InChIKey |
SSWXQDWEQJONGZ-VXMHZBNVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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846.848
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Polar area
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348.3
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Complexity
|
1680.29589
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xlogp Value
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-5.4327
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Heavy Count
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60
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Rot Bonds
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23
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Hbond acc
|
14
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker