Linker Information
General Information of This Linker
| Linker ID |
LIN0NKCHM
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| Linker Name |
P5 (PEG12)- VC-PAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C52H85N6O21PS
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| Isosmiles |
CC(C)C(C(N[C@H](C(NC1=CC=C(C=C1)COC(O)=O)=O)CCCNC(N)=O)=O)NC(C2=CC=C(C=C2)NP(/C=C\S)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)=O
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| InChI |
InChI=1S/C52H85N6O21PS/c1-41(2)47(50(62)56-46(4-3-13-54-51(53)63)49(61)55-44-9-5-42(6-10-44)40-78-52(64)65)57-48(60)43-7-11-45(12-8-43)58-80(66,38-39-81)79-37-36-77-35-34-76-33-32-75-31-30-74-29-28-73-27-26-72-25-24-71-23-22-70-21-20-69-19-18-68-17-16-67-15-14-59/h5-12,38-39,41,46-47,59,81H,3-4,13-37,40H2,1-2H3,(H,55,61)(H,56,62)(H,57,60)(H,58,66)(H,64,65)(H3,53,54,63)/b39-38-/t46-,47?,80?/m0/s1
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| InChIKey |
UHQVRVABPMELTM-SWGMWQNVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1193.314
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Polar area
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349.04
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Complexity
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1957.588432
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xlogp Value
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3.4051
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Heavy Count
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81
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Rot Bonds
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52
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Hbond acc
|
21
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker