Linker Information
General Information of This Linker
| Linker ID |
LIN0NHWGP
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P1-P2-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C67H97N17O26
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| Isosmiles |
O=C(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)CNC(CNC(CCOCCOCC(N=N2)=CN2CCOCCN(C(CCOCCN(N=N3)C=C3COCCOCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CCNC(CCC(NC[C@H]5[C@@H](O)[C@@H](O)[C@H](O)[C@H](O5)O)=O)=O)=O)=O
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| InChI |
InChI=1S/C67H97N17O26/c85-51(11-12-52(86)69-33-50-62(98)63(99)64(100)67(103)110-50)68-16-17-82(18-24-107-26-20-84-41-47(79-81-84)43-109-30-28-106-22-14-54(88)71-35-56(90)73-37-58(92)77-49(66(102)75-39-61(96)97)32-45-9-5-2-6-10-45)59(93)15-23-104-25-19-83-40-46(78-80-83)42-108-29-27-105-21-13-53(87)70-34-55(89)72-36-57(91)76-48(65(101)74-38-60(94)95)31-44-7-3-1-4-8-44/h1-10,40-41,48-50,62-64,67,98-100,103H,11-39,42-43H2,(H,68,85)(H,69,86)(H,70,87)(H,71,88)(H,72,89)(H,73,90)(H,74,101)(H,75,102)(H,76,91)(H,77,92)(H,94,95)(H,96,97)/t48-,49-,50-,62+,63+,64-,67-/m0/s1
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| InChIKey |
MMULKHNLPKAWEH-LWMMDSQFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1556.606
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Polar area
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592.86
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Complexity
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3392.8233
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xlogp Value
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-8.1978
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Heavy Count
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110
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Rot Bonds
|
56
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Hbond acc
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30
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker