Linker Information
General Information of This Linker
| Linker ID |
LIN0NHQKB
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| Linker Name |
Maleimidyl - PEG3 - benzyl - disulfide - dimethyl linker
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C25H35N3O7S
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| Isosmiles |
O=C(NCCCOCCOCCOCCCNC(CCN1C(C=CC1=O)=O)=O)CC2=C(S)C=CC=C2
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| InChI |
InChI=1S/C25H35N3O7S/c29-22(9-12-28-24(31)7-8-25(28)32)26-10-3-13-33-15-17-35-18-16-34-14-4-11-27-23(30)19-20-5-1-2-6-21(20)36/h1-2,5-8,36H,3-4,9-19H2,(H,26,29)(H,27,30)
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| InChIKey |
IXCOFAFAMOZHTB-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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521.636
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Polar area
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123.27
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Complexity
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830.5442158
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xlogp Value
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0.8953
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Heavy Count
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36
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Rot Bonds
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19
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Hbond acc
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8
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.41 nM
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High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||