Linker Information
General Information of This Linker
| Linker ID |
LIN0NGLGQ
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| Linker Name |
CN112638426B +ADC2+Linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Unclear
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| Structure |
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| Formula |
C22H26N4O7
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| Isosmiles |
O=C(N1CC2CCC(C(NCCNC(C3=C([N+]([O-])=O)C=CC(CO)=C3)=O)=O)CC2)C=CC1=O
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| InChI |
InChI=1S/C22H26N4O7/c27-13-15-3-6-18(26(32)33)17(11-15)22(31)24-10-9-23-21(30)16-4-1-14(2-5-16)12-25-19(28)7-8-20(25)29/h3,6-8,11,14,16,27H,1-2,4-5,9-10,12-13H2,(H,23,30)(H,24,31)
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| InChIKey |
CDQNRPIOCIYWEN-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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458.471
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Polar area
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158.95
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Complexity
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924.2504472
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xlogp Value
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0.6645
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Heavy Count
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33
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Rot Bonds
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9
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Hbond acc
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7
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
cN112638426B ADC2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.26 nM
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| Method Description |
A Cell line test on HCC1954
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| In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.45 nM
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| Method Description |
A Cell line test on NCI-N87
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.69 nM
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| Method Description |
A Cell line test on BT-474
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
52.46 nM
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| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
99.84 nM
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| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
References