Linker Information
General Information of This Linker
| Linker ID |
LIN0NFMIB
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN113549127A-ADC-15-linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C31H47N11O10S
|
|||||
| Isosmiles |
CC(C)[C@H](NC(OCC(NCCOCCOCCN1C=C(N=N1)CCCN2C(C(C=NC(S)=N3)=C3C2)=O)=O)=O)C(N[C@H](C(O)=O)CCCNC(N)=O)=O
|
|||||
| InChI |
InChI=1S/C31H47N11O10S/c1-19(2)25(26(44)36-22(28(46)47)6-3-7-34-29(32)48)38-31(49)52-18-24(43)33-8-11-50-13-14-51-12-10-42-16-20(39-40-42)5-4-9-41-17-23-21(27(41)45)15-35-30(53)37-23/h15-16,19,22,25H,3-14,17-18H2,1-2H3,(H,33,43)(H,36,44)(H,38,49)(H,46,47)(H3,32,34,48)(H,35,37,53)/t22-,25-/m0/s1
|
|||||
| InChIKey |
HJOOIPAVTHXPCB-DHLKQENFSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
765.851
|
Polar area
|
284.21
|
||
|
Complexity
|
1481.401875
|
xlogp Value
|
-1.1365
|
|||
|
Heavy Count
|
53
|
Rot Bonds
|
24
|
|||
|
Hbond acc
|
15
|
Hbond Donor
|
7
|
|||
Each Antibody-drug Conjugate Related to This Linker