Linker Information
General Information of This Linker
| Linker ID |
LIN0NETYQ
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| Linker Name |
DM-III Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C53H77N13O15
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| Isosmiles |
CN(C(C1=O)=C)C(CC[C@H](C(O)=O)NC([C@@H](C)[C@H](/C=C/C(C)=C/[C@H](C)[C@@H](OC)CC2=CC=CC=C2)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](C(O)=O)NC([C@H](CCCCN(N=N3)C=C3COC(O)=O)NC([C@@H](C)N1)=O)=O)C)=O)=O)=O)=O
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| InChI |
InChI=1S/C53H77N13O15/c1-29(25-30(2)41(80-8)26-35-15-10-9-11-16-35)19-20-37-31(3)44(68)61-40(50(74)75)21-22-42(67)65(7)34(6)47(71)57-33(5)46(70)60-38(17-12-13-24-66-27-36(63-64-66)28-81-53(78)79)49(73)62-43(51(76)77)32(4)45(69)59-39(48(72)58-37)18-14-23-56-52(54)55/h9-11,15-16,19-20,25,27,30-33,37-41,43H,6,12-14,17-18,21-24,26,28H2,1-5,7-8H3,(H,57,71)(H,58,72)(H,59,69)(H,60,70)(H,61,68)(H,62,73)(H,74,75)(H,76,77)(H,78,79)(H4,54,55,56)/b20-19+,29-25+/t30-,31-,32-,33+,37-,38-,39-,40+,41-,43+/m0/s1
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| InChIKey |
CYFIMLSZJQEIGY-YCAYZCDQSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1136.275
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Polar area
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417.88
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Complexity
|
2522.86125
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xlogp Value
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0.43857
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Heavy Count
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81
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Rot Bonds
|
20
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Hbond acc
|
16
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker