Linker Information
General Information of This Linker
| Linker ID |
LIN0NETPS
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|---|---|---|---|---|---|---|
| Linker Name |
CN112341521B+Linker20
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C42H62N10O12S
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| Isosmiles |
CC([C@H](N(C)C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCN(CC2=C3C=NC(S(C)(=O)=O)=N2)C3=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)C(N[C@@H](C(C)C)C(O)=O)=O)C
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| InChI |
InChI=1S/C42H62N10O12S/c1-23(2)32(49-31(53)13-9-10-19-52-21-30-28(38(52)57)20-45-41(48-30)65(8,62)63)36(55)47-29(12-11-18-44-40(43)60)35(54)46-27-16-14-26(15-17-27)22-64-42(61)51(7)34(25(5)6)37(56)50-33(24(3)4)39(58)59/h14-17,20,23-25,29,32-34H,9-13,18-19,21-22H2,1-8H3,(H,46,54)(H,47,55)(H,49,53)(H,50,56)(H,58,59)(H3,43,44,60)/t29-,32-,33-,34-/m0/s1
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| InChIKey |
VWOSJXBMQXJHCI-UYDQTSAYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
931.083
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Polar area
|
318.59
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Complexity
|
2079.436973
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xlogp Value
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1.5374
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Heavy Count
|
65
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Rot Bonds
|
24
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Hbond acc
|
13
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker