Linker Information
General Information of This Linker
| Linker ID |
LIN0NDDZH
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| Linker Name |
MC-Val-Ala-RG-12
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C45H64N8O11
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| Isosmiles |
O=C(N[C@@H](C)C(NC1=CC=C(COC(NCC2=CC=CC=C2N(CCN3CCN(CCOCCOC)CC3)C(O)=O)=O)C=C1)=O)[C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O
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| InChI |
InChI=1S/C45H64N8O11/c1-32(2)41(49-38(54)12-6-5-9-19-53-39(55)17-18-40(53)56)43(58)47-33(3)42(57)48-36-15-13-34(14-16-36)31-64-44(59)46-30-35-10-7-8-11-37(35)52(45(60)61)25-24-50-20-22-51(23-21-50)26-27-63-29-28-62-4/h7-8,10-11,13-18,32-33,41H,5-6,9,12,19-31H2,1-4H3,(H,46,59)(H,47,58)(H,48,57)(H,49,54)(H,60,61)/t33-,41-/m0/s1
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| InChIKey |
XUQRHJNBHQAVTR-GCBNJDDTSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
893.052
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Polar area
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228.49
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Complexity
|
1809.772534
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xlogp Value
|
2.9474
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Heavy Count
|
64
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Rot Bonds
|
26
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Hbond acc
|
12
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker