Linker Information
General Information of This Linker
| Linker ID |
LIN0NCHKU
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| Linker Name |
Anti-Her2-AL1- LP1 LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H83N11O17
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(COC1CC(N=NN2CCOCCOCCOCCN)=C2CCCC1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C
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| InChI |
InChI=1S/C50H83N11O17/c1-36(2)46(48(67)57-40(7-5-15-54-49(52)68)47(66)56-38-11-9-37(10-12-38)34-78-50(69)55-33-45(64)65)58-43(62)13-18-70-22-26-74-30-31-76-28-24-72-20-16-53-44(63)35-77-39-6-3-4-8-42-41(32-39)59-60-61(42)17-21-73-25-29-75-27-23-71-19-14-51/h9-12,36,39-40,46H,3-8,13-35,51H2,1-2H3,(H,53,63)(H,55,69)(H,56,66)(H,57,67)(H,58,62)(H,64,65)(H3,52,54,68)/t39?,40-,46-/m0/s1
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| InChIKey |
DPBBRQGIUXPFDY-IMGUCOJTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1110.274
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Polar area
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377.72
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Complexity
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1949.237179
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xlogp Value
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-0.463
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Heavy Count
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78
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Rot Bonds
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43
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Hbond acc
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20
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Hbond Donor
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9
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1H21234N-N297Q-LP1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.738 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-1/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References