Linker Information
General Information of This Linker
| Linker ID |
LIN0NARJA
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| Linker Name |
L4-P1 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C49H77N9O19
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| Isosmiles |
CC([C@H](NC(CCOCCN1C(C=CC1=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC(COCC(N=N3)=CN3CCOCCOCCOCCOCCOCCOCCOCCOC)=C(COC(O)=O)C=C2)=O)=O)C
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| InChI |
InChI=1S/C49H77N9O19/c1-36(2)45(54-42(59)10-14-68-16-13-58-43(60)8-9-44(58)61)47(63)53-41(5-4-11-51-48(50)64)46(62)52-39-7-6-37(34-77-49(65)66)38(31-39)33-76-35-40-32-57(56-55-40)12-15-69-19-20-71-23-24-73-27-28-75-30-29-74-26-25-72-22-21-70-18-17-67-3/h6-9,31-32,36,41,45H,4-5,10-30,33-35H2,1-3H3,(H,52,62)(H,53,63)(H,54,59)(H,65,66)(H3,50,51,64)/t41-,45-/m0/s1
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| InChIKey |
RIFJVPLHRUKCCS-XMUJVIFGSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1096.199
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Polar area
|
349.34
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Complexity
|
1978.89235
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xlogp Value
|
0.2964
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Heavy Count
|
77
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Rot Bonds
|
46
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Hbond acc
|
21
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker