Linker Information
General Information of This Linker
| Linker ID |
LIN0NALNI
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| Linker Name |
IG-L-68 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C83H126FN23O29
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| Isosmiles |
C[C@H](NC(CCC1=CC=C(N2C(C=CC2=O)=O)C(F)=C1OCCCC(N(C)CC(N(CC(N(C)CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(C)CC(N(CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(O)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)C)=O)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)=O)C)=O)=O)=O)C(N[C@@H](C)C(O)=O)=O
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| InChI |
InChI=1S/C83H126FN23O29/c1-52(82(133)86-53(2)83(134)135)85-56(108)28-26-54-25-27-55(107-58(110)29-30-59(107)111)80(84)81(54)136-31-23-24-57(109)87(3)32-60(112)88(4)33-61(113)89(5)34-62(114)90(6)35-63(115)91(7)36-64(116)92(8)37-65(117)93(9)38-66(118)94(10)39-67(119)95(11)40-68(120)96(12)41-69(121)97(13)42-70(122)98(14)43-71(123)99(15)44-72(124)100(16)45-73(125)101(17)46-74(126)102(18)47-75(127)103(19)48-76(128)104(20)49-77(129)105(21)50-78(130)106(22)51-79(131)132/h25,27,29-30,52-53H,23-24,26,28,31-51H2,1-22H3,(H,85,108)(H,86,133)(H,131,132)(H,134,135)/t52-,53-/m0/s1
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| InChIKey |
WMLTZPNCFWROGB-BNLBYEDMSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1929.051
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Polar area
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585.61
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Complexity
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.
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xlogp Value
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-10.3067
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Heavy Count
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136
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Rot Bonds
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53
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Hbond acc
|
27
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Hbond Donor
|
4
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Each Antibody-drug Conjugate Related to This Linker