Linker Information
General Information of This Linker
| Linker ID |
LIN0NAGRZ
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|---|---|---|---|---|---|---|
| Linker Name |
ADCProductionexampleNo.2Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C44H65N9O16
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| Isosmiles |
CC(C)[C@H](NC([C@H](CC(N[C@@H](CCO1)C1=O)=O)NC(CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O
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| InChI |
InChI=1S/C44H65N9O16/c1-28(2)39(42(62)51-31(4-3-14-47-44(45)64)40(60)48-30-7-5-29(27-54)6-8-30)52-41(61)33(26-36(57)49-32-12-18-69-43(32)63)50-35(56)13-17-65-20-22-67-24-25-68-23-21-66-19-15-46-34(55)11-16-53-37(58)9-10-38(53)59/h5-10,28,31-33,39,54H,3-4,11-27H2,1-2H3,(H,46,55)(H,48,60)(H,49,57)(H,50,56)(H,51,62)(H,52,61)(H3,45,47,64)/t31-,32-,33-,39-/m0/s1
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| InChIKey |
BHJNVEAEPMFKMK-AUUMHAPGSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
976.051
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Polar area
|
350.55
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Complexity
|
1826.155549
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xlogp Value
|
-2.6141
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Heavy Count
|
69
|
Rot Bonds
|
34
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Hbond acc
|
16
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker