Linker Information
General Information of This Linker
| Linker ID |
LIN0MWXQO
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| Linker Name |
LL3 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C39H60N8O13
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| Isosmiles |
CC([C@H](NC(C)=O)C(N[C@@H](CCCNC(N)=O)C(NC1=CC(OCC(NCCCOCCOCCOCCCNC(CCN2C(C=CC2=O)=O)=O)=O)=C(C=C1)CO)=O)=O)C
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| InChI |
InChI=1S/C39H60N8O13/c1-26(2)36(44-27(3)49)38(55)46-30(7-4-13-43-39(40)56)37(54)45-29-9-8-28(24-48)31(23-29)60-25-33(51)42-15-6-18-58-20-22-59-21-19-57-17-5-14-41-32(50)12-16-47-34(52)10-11-35(47)53/h8-11,23,26,30,36,48H,4-7,12-22,24-25H2,1-3H3,(H,41,50)(H,42,51)(H,44,49)(H,45,54)(H,46,55)(H3,40,43,56)/t30-,36-/m0/s1
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| InChIKey |
LFCDBLSOBWUXSS-ARPOTICCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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848.952
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Polar area
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295.15
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Complexity
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1529.63477
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xlogp Value
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-1.0323
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Heavy Count
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60
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Rot Bonds
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31
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Hbond acc
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13
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Hbond Donor
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8
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
12.7 nM
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High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||