Linker Information
General Information of This Linker
| Linker ID |
LIN0MWQZQ
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| Linker Name |
Mal-DBCO-PEG3
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| Linker Type |
Flexible reactive (thiol) linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C36H42N6O9
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| Isosmiles |
COCCOCCOCCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCCCCC(=O)ON3C(=O)C=CC3=O)c2-c2ccccc21
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| InChI |
InChI=1S/C36H42N6O9/c1-48-21-22-50-24-23-49-20-18-37-30(43)14-15-31(44)40-25-26-9-4-5-10-27(26)35-36(28-11-6-7-12-29(28)40)41(39-38-35)19-8-2-3-13-34(47)51-42-32(45)16-17-33(42)46/h4-7,9-12,16-17H,2-3,8,13-15,18-25H2,1H3,(H,37,43)
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| InChIKey |
VGZLIDHQUNGWDW-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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702.765
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Polar area
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171.49
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Complexity
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51
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xlogp Value
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2.9783
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Heavy Count
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51
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Rot Bonds
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19
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Hbond acc
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12
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Hbond Donor
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1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Homo-Ang2-Cys5.5 conjugate DAR 4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
77.20 nM
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Positive EGFR vIII expression (EGFR vIII+++/++) | ||
| Method Description |
ADC cell viability assay in U87EGFR-Luc (EGFRvIII+ ) and HEK293 (EGFRvIII - ) cells.
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| In Vitro Model | Glioblastoma | U87EGFR-Luc cells | CVCL_0022 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 100.00 nM | Negative EGFR vIII expression (EGFR vIII-) | ||
| Method Description |
ADC cell viability assay in U87EGFR-Luc (EGFRvIII+ ) and HEK293 (EGFRvIII - ) cells.
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| In Vitro Model | Glioblastoma | U87EGFR-Luc cells | CVCL_0022 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
80.80%
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Positive EGFR vIII expression (EGFR vIII+++/++) | ||
| Method Description |
ADC cell viability assay in U87EGFR-Luc (EGFRvIII+ ) and HEK293 (EGFRvIII - ) cells.
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| In Vitro Model | Glioblastoma | U87EGFR-Luc cells | CVCL_0022 | ||
References
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