Linker Information
General Information of This Linker
| Linker ID |
LIN0MWLNP
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| Linker Name |
WO2024140449A1+ADC5+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C17H31BrN4O7
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| Isosmiles |
O=C(NCCOCCOCCC(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)CBr
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| InChI |
InChI=1S/C17H31BrN4O7/c18-11-15(24)20-6-8-29-10-9-28-7-4-14(23)21-12-16(25)22-13(17(26)27)3-1-2-5-19/h13H,1-12,19H2,(H,20,24)(H,21,23)(H,22,25)(H,26,27)/t13-/m0/s1
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| InChIKey |
LXBQUZVOBQTMKN-ZDUSSCGKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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483.36
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Polar area
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169.08
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Complexity
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464.4299824
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xlogp Value
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-1.2646
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Heavy Count
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29
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Rot Bonds
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18
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Hbond acc
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7
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 250 nM | |||
| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||