Linker Information
General Information of This Linker
| Linker ID |
LIN0MUGER
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|---|---|---|---|---|---|---|
| Linker Name |
aHer2- (BL1-LP13)<sub>14.88</sub> Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C206H316N40O64S4
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| Isosmiles |
CC1=NN=C(C2=CC=C(CNC(CN(CC(NCC3=CC=C(C4=NN=C(C5=C4CCCCCC5OCC(NCCOCCOCCC(NC(COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(NC(CCCNC(N)=O)C(NC6=CC=C(C=C6)CO)=O)=O)C(C)C)=O)=O)=O)COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC7=CC=C(C=C7)CO)=O)=O)C(C)C)=O)=O)=O)=O)=O)C)C=C3)=O)CCOCCOCCOCCNC(C)=O)=O)C=C2)C8=C1C(OCC(NCCOCCOCCC(NC(COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(NC(CCCNC(N)=O)C(NC9=CC=C(C=C9)CO)=O)=O)C(C)C)=O)=O)=O)COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC%10=CC=C(C=C%10)CO)=O)=O)C(C)C)=O)=O)=O)=O)=O)CCCCC8.[S].[S].[S].[S]
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| InChI |
InChI=1S/C206H316N40O64.4S/c1-132(2)185(199(282)234-155(24-18-72-218-203(207)286)191(274)226-147-46-34-141(122-247)35-47-147)238-195(278)159(54-58-179(266)267)230-171(258)68-86-292-104-108-297-95-77-212-165(252)62-90-305-126-151(127-306-91-63-166(253)213-78-96-298-109-105-293-87-69-172(259)231-160(55-59-180(268)269)196(279)239-186(133(3)4)200(283)235-156(25-19-73-219-204(208)287)192(275)227-148-48-36-142(123-248)37-49-148)224-169(256)66-84-290-102-112-301-99-81-216-177(264)130-309-163-28-16-12-14-22-153-183(163)136(9)242-244-189(153)145-42-30-139(31-43-145)118-222-175(262)120-246(83-101-303-115-117-304-116-114-296-94-76-211-138(11)251)121-176(263)223-119-140-32-44-146(45-33-140)190-154-23-15-13-17-29-164(184(154)137(10)243-245-190)310-131-178(265)217-82-100-302-113-103-291-85-67-170(257)225-152(128-307-92-64-167(254)214-79-97-299-110-106-294-88-70-173(260)232-161(56-60-181(270)271)197(280)240-187(134(5)6)201(284)236-157(26-20-74-220-205(209)288)193(276)228-149-50-38-143(124-249)39-51-149)129-308-93-65-168(255)215-80-98-300-111-107-295-89-71-174(261)233-162(57-61-182(272)273)198(281)241-188(135(7)8)202(285)237-158(27-21-75-221-206(210)289)194(277)229-150-52-40-144(125-250)41-53-150;;;;/h30-53,132-135,151-152,155-164,185-188,247-250H,12-29,54-131H2,1-11H3,(H,211,251)(H,212,252)(H,213,253)(H,214,254)(H,215,255)(H,216,264)(H,217,265)(H,222,262)(H,223,263)(H,224,256)(H,225,257)(H,226,274)(H,227,275)(H,228,276)(H,229,277)(H,230,258)(H,231,259)(H,232,260)(H,233,261)(H,234,282)(H,235,283)(H,236,284)(H,237,285)(H,238,278)(H,239,279)(H,240,280)(H,241,281)(H,266,267)(H,268,269)(H,270,271)(H,272,273)(H3,207,218,286)(H3,208,219,287)(H3,209,220,288)(H3,210,221,289);;;;/t151?,152?,155-,156?,157-,158?,159-,160-,161-,162-,163?,164?,185-,186-,187-,188-;;;;/m0..../s1
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| InChIKey |
QMZALSXOLYRMLT-LEPVXAMHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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4505.278
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Polar area
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1484.93
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Complexity
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.
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xlogp Value
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1.63134
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Heavy Count
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314
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Rot Bonds
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168
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Hbond acc
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65
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Hbond Donor
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43
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Each Antibody-drug Conjugate Related to This Linker