Linker Information
General Information of This Linker
| Linker ID |
LIN0MTQFT
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| Linker Name |
Anti-Her2-AL1- LP40 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C86H136N20O32
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1C(OCC(NCCOCCOCCC(NC(COCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)COCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)O)CCCCC2
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| InChI |
InChI=1S/C86H136N20O32/c1-53(2)74(81(123)100-60(10-8-30-91-83(88)125)77(119)96-57-18-14-55(15-19-57)48-137-85(127)93-46-72(115)116)102-79(121)62(22-24-70(111)112)98-67(108)27-35-134-50-59(95-66(107)26-34-129-40-42-131-38-32-90-69(110)52-136-65-13-7-5-6-12-64-76(65)104-105-106(64)33-39-132-43-45-133-44-41-130-37-29-87)51-135-36-28-68(109)99-63(23-25-71(113)114)80(122)103-75(54(3)4)82(124)101-61(11-9-31-92-84(89)126)78(120)97-58-20-16-56(17-21-58)49-138-86(128)94-47-73(117)118/h14-21,53-54,59-63,65,69,74-75,90,110H,5-13,22-52,87H2,1-4H3,(H,93,127)(H,94,128)(H,95,107)(H,96,119)(H,97,120)(H,98,108)(H,99,109)(H,100,123)(H,101,124)(H,102,121)(H,103,122)(H,111,112)(H,113,114)(H,115,116)(H,117,118)(H3,88,91,125)(H3,89,92,126)/t60-,61-,62-,63-,65?,69?,74-,75-/m0/s1
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| InChIKey |
OFFGCYKQYAAUJO-QHNIWSGJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1962.142
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Polar area
|
760.83
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Complexity
|
.
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xlogp Value
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-2.1633
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Heavy Count
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138
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Rot Bonds
|
73
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Hbond acc
|
33
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Hbond Donor
|
22
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Each Antibody-drug Conjugate Related to This Linker