Linker Information
General Information of This Linker
| Linker ID |
LIN0MTEYC
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| Linker Name |
CN119630431A-ADC-81-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H41N5O10S2
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| Isosmiles |
O=C(N1CCOCCOCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O)=O)C(SC3=CC=CC=C3)=C(SC4=CC=CC=C4)C1=O
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| InChI |
InChI=1S/C38H41N5O10S2/c44-30(39-23-31(45)40-24-32(46)42-29(36(49)41-25-33(47)48)22-26-10-4-1-5-11-26)16-18-52-20-21-53-19-17-43-37(50)34(54-27-12-6-2-7-13-27)35(38(43)51)55-28-14-8-3-9-15-28/h1-15,29H,16-25H2,(H,39,44)(H,40,45)(H,41,49)(H,42,46)(H,47,48)/t29-/m0/s1
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| InChIKey |
PZQNOOMVAXZTAU-LJAQVGFWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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791.905
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Polar area
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209.54
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Complexity
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1695.609672
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xlogp Value
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1.7354
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Heavy Count
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55
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Rot Bonds
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23
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Hbond acc
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11
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 6 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.029 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||
WO2024043319A1 5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||