Linker Information
General Information of This Linker
| Linker ID |
LIN0MSNTM
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|---|---|---|---|---|---|---|
| Name |
Mal-PEG4-Val-Lys (PEG12)-Cit-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H83N7O24
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| Isosmiles |
CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(C=C1)CO)=O)CCCNC(NCCOCOCOCOCOCOCOCOCOCOCOCOC)=O)=O)NC(CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O
|
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| InChI |
InChI=1S/C50H83N7O24/c1-39(2)47(56-44(60)13-18-67-21-23-69-25-26-70-24-22-68-19-15-51-43(59)12-17-57-45(61)10-11-46(57)62)49(64)55-42(48(63)54-41-8-6-40(27-58)7-9-41)5-4-14-52-50(65)53-16-20-71-29-73-31-75-33-77-35-79-37-81-38-80-36-78-34-76-32-74-30-72-28-66-3/h6-11,39,42,47,58H,4-5,12-38H2,1-3H3,(H,51,59)(H,54,63)(H,55,64)(H,56,60)(H2,52,53,65)/t42-,47-/m0/s1
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| InChIKey |
PFKPDSZMLVEOMS-VNKGTZQQSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1166.239
|
Polar area
|
362.82
|
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Complexity
|
1770.107258
|
xlogp Value
|
-0.9283
|
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Heavy Count
|
81
|
Rot Bonds
|
54
|
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Hbond acc
|
24
|
Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker