Linker Information
General Information of This Linker
| Linker ID |
LIN0MRDCH
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN119326907A Trastuzumab-GDP-D-P2/P8-P4-GGFG-Dxd Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C92H147N17O36
|
|||||
| Isosmiles |
O=C(NCC(NCC(NC(C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)CCOCCOCCOCCOCC(N=N2)=CN2CCOCCOCCN(CCNC(CCC(NC[C@@H]3C[C@H](O)[C@@H](O)C[C@@H]3O)=O)=O)C(CCOCCOCCOCCOCCOCCOCCOCCOCN4C=C(N=N4)CCOCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(NCC(O)=O)=O)=O)=O)=O)=O
|
|||||
| InChI |
InChI=1S/C92H147N17O36/c110-77-58-79(112)78(111)57-72(77)59-94-81(114)12-11-80(113)93-17-18-107(19-25-132-31-32-133-26-20-108-67-74(104-105-108)68-144-53-51-142-49-47-136-35-29-130-23-15-83(116)96-61-85(118)98-63-87(120)102-76(92(127)100-65-90(124)125)56-71-9-5-2-6-10-71)88(121)16-24-131-30-36-137-39-40-138-41-42-139-43-44-140-45-46-141-48-50-143-52-54-145-69-109-66-73(103-106-109)13-21-128-27-33-134-37-38-135-34-28-129-22-14-82(115)95-60-84(117)97-62-86(119)101-75(91(126)99-64-89(122)123)55-70-7-3-1-4-8-70/h1-10,66-67,72,75-79,110-112H,11-65,68-69H2,(H,93,113)(H,94,114)(H,95,115)(H,96,116)(H,97,117)(H,98,118)(H,99,126)(H,100,127)(H,101,119)(H,102,120)(H,122,123)(H,124,125)/t72-,75-,76?,77-,78-,79-/m0/s1
|
|||||
| InChIKey |
UMYSMNRLBMWRBX-SRXWWYMBSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
2067.271
|
Polar area
|
674.16
|
||
|
Complexity
|
.
|
xlogp Value
|
-6.3058
|
|||
|
Heavy Count
|
145
|
Rot Bonds
|
92
|
|||
|
Hbond acc
|
40
|
Hbond Donor
|
15
|
|||
Each Antibody-drug Conjugate Related to This Linker