Linker Information
General Information of This Linker
| Linker ID |
LIN0MQJYW
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| Linker Name |
CN110997010A ADC-33 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C72H101N13O19S3
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| Isosmiles |
CC([C@H](N(C)C(CCCCCN1C(CC(SCC(NC(C(NC(CSCCC(N2CN(C(C=C)=O)CN(C(C=C)=O)C2)=O)=O)CSC(CC3=O)C(N3CCCCCC(N(C)[C@H](C(N[C@@H](C)C(NC4=CC=C(CO)C=C4)=O)=O)C(C)C)=O)=O)=O)C(O)=O)C1=O)=O)=O)C(N[C@@H](C)C(NC5=CC=C(CO)C=C5)=O)=O)C
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| InChI |
InChI=1S/C72H101N13O19S3/c1-11-56(89)81-40-82(57(90)12-2)42-83(41-81)60(93)29-32-105-39-55(88)77-51(37-106-53-33-61(94)84(70(53)101)30-17-13-15-19-58(91)79(9)63(43(3)4)68(99)73-45(7)65(96)75-49-25-21-47(35-86)22-26-49)67(98)78-52(72(103)104)38-107-54-34-62(95)85(71(54)102)31-18-14-16-20-59(92)80(10)64(44(5)6)69(100)74-46(8)66(97)76-50-27-23-48(36-87)24-28-50/h11-12,21-28,43-46,51-54,63-64,86-87H,1-2,13-20,29-42H2,3-10H3,(H,73,99)(H,74,100)(H,75,96)(H,76,97)(H,77,88)(H,78,98)(H,103,104)/t45-,46-,51?,52?,53?,54?,63-,64-/m0/s1
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| InChIKey |
CFBKSCSYHZNFDW-NGSVEBBFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1548.873
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Polar area
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428.67
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Complexity
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3395.783988
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xlogp Value
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1.9874
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Heavy Count
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107
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Rot Bonds
|
43
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Hbond acc
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21
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker