Linker Information
General Information of This Linker
| Linker ID |
LIN0MMSLV
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P1/P1-P4-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C75H113N17O30
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| Isosmiles |
O=C(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)CNC(CNC(CCOCCOCCOCCOCC(N=N2)=CN2CCOCCN(C(CCOCCN(N=N3)C=C3COCCOCCOCCOCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CCNC(CCC(NC[C@H](O5)[C@@H](O)[C@@H](O)[C@H](O)[C@H]5O)=O)=O)=O)=O
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| InChI |
InChI=1S/C75H113N17O30/c93-59(11-12-60(94)77-41-58-70(106)71(107)72(108)75(111)122-58)76-16-17-90(18-24-115-26-20-92-49-55(87-89-92)51-121-38-36-119-34-32-117-30-28-114-22-14-62(96)79-43-64(98)81-45-66(100)85-57(74(110)83-47-69(104)105)40-53-9-5-2-6-10-53)67(101)15-23-112-25-19-91-48-54(86-88-91)50-120-37-35-118-33-31-116-29-27-113-21-13-61(95)78-42-63(97)80-44-65(99)84-56(73(109)82-46-68(102)103)39-52-7-3-1-4-8-52/h1-10,48-49,56-58,70-72,75,106-108,111H,11-47,50-51H2,(H,76,93)(H,77,94)(H,78,95)(H,79,96)(H,80,97)(H,81,98)(H,82,109)(H,83,110)(H,84,99)(H,85,100)(H,102,103)(H,104,105)/t56-,57-,58-,70+,71+,72-,75-/m0/s1
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| InChIKey |
OJUFFVQHVQVXQH-UQPPDCLGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1732.818
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Polar area
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629.78
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Complexity
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.
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xlogp Value
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-8.1314
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Heavy Count
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122
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Rot Bonds
|
68
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Hbond acc
|
34
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker