Linker Information
General Information of This Linker
| Linker ID |
LIN0MMBGN
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
aHer2- (AL6-LP13)<sub>6.5</sub> Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C97H147N19O30
|
|||||
| Isosmiles |
O=C(NCCOCCOCCC(NC(COCCC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)C(C)C)=O)=O)=O)COCCC(NCCOCCOCCC(N[C@H](C(N[C@H](C(NC(CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C(C)C)=O)CCC(O)=O)=O)=O)=O)COC(CCCCC3)C4=C3C(C5=CC=C(CNC(C)=O)C=C5)=NN=C4
|
|||||
| InChI |
InChI=1S/C97H147N19O30/c1-62(2)87(94(134)112-74(12-9-36-103-96(98)136)90(130)108-69-23-17-66(57-117)18-24-69)114-92(132)76(27-29-85(126)127)110-82(123)34-42-139-50-52-141-46-38-100-79(120)31-44-144-59-71(107-81(122)33-41-138-49-54-143-48-40-102-84(125)61-146-78-14-8-6-7-11-72-73(78)56-106-116-89(72)68-21-15-65(16-22-68)55-105-64(5)119)60-145-45-32-80(121)101-39-47-142-53-51-140-43-35-83(124)111-77(28-30-86(128)129)93(133)115-88(63(3)4)95(135)113-75(13-10-37-104-97(99)137)91(131)109-70-25-19-67(58-118)20-26-70/h15-26,56,62-63,71,74-78,87-88,117-118H,6-14,27-55,57-61H2,1-5H3,(H,100,120)(H,101,121)(H,102,125)(H,105,119)(H,107,122)(H,108,130)(H,109,131)(H,110,123)(H,111,124)(H,112,134)(H,113,135)(H,114,132)(H,115,133)(H,126,127)(H,128,129)(H3,98,103,136)(H3,99,104,137)/t71?,74-,75?,76-,77-,78?,87-,88-/m0/s1
|
|||||
| InChIKey |
OWRBQPUDIYJUOH-FPYXMAFJSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
2059.346
|
Polar area
|
712.45
|
||
|
Complexity
|
.
|
xlogp Value
|
-0.02
|
|||
|
Heavy Count
|
146
|
Rot Bonds
|
76
|
|||
|
Hbond acc
|
30
|
Hbond Donor
|
21
|
|||
Each Antibody-drug Conjugate Related to This Linker