Linker Information
General Information of This Linker
| Linker ID |
LIN0MLUFK
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| Linker Name |
ADC-16 BGB-C-348 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H52N6O15
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(CCC(O)=O)=O)=O)=O)[C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)CCC(NC[C@H](O3)[C@H](O)[C@@H](O)[C@H](O)[C@H]3CO)=O
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| InChI |
InChI=1S/C38H52N6O15/c45-21-27-36(56)37(57)35(55)26(59-27)18-39-28(47)12-10-23(42-29(48)9-5-2-6-16-44-32(51)13-14-33(44)52)38(58)41-19-30(49)40-20-31(50)43-24(25(46)11-15-34(53)54)17-22-7-3-1-4-8-22/h1,3-4,7-8,13-14,23-24,26-27,35-37,45,55-57H,2,5-6,9-12,15-21H2,(H,39,47)(H,40,49)(H,41,58)(H,42,48)(H,43,50)(H,53,54)/t23-,24-,26-,27+,35-,36+,37+/m0/s1
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| InChIKey |
NYOUHHNRAOTGSZ-JGQUGZHASA-N
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| Pharmaceutical Properties |
Molecule Weight
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832.861
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Polar area
|
327.4
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Complexity
|
1598.298893
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xlogp Value
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-3.9108
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Heavy Count
|
59
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Rot Bonds
|
25
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Hbond acc
|
14
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker