Linker Information
General Information of This Linker
| Linker ID |
LIN0MKGRL
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
T-14 linker
|
|||||
| Linker Type |
Beta-glucuronide based linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C31H43N5O16S
|
|||||
| Isosmiles |
O[C@@H]1[C@H](O)[C@@H](O)C(OC2=C(OS(=O)(O)=O)C=C(C(N(C)CCOCCCN3C=C(N=N3)COCCOCCCN4C(C=CC4=O)=O)=O)C=C2)O[C@@H]1CO
|
|||||
| InChI |
InChI=1S/C31H43N5O16S/c1-34(30(43)20-4-5-22(23(16-20)52-53(44,45)46)50-31-29(42)28(41)27(40)24(18-37)51-31)10-13-47-11-2-8-35-17-21(32-33-35)19-49-15-14-48-12-3-9-36-25(38)6-7-26(36)39/h4-7,16-17,24,27-29,31,37,40-42H,2-3,8-15,18-19H2,1H3,(H,44,45,46)/t24-,27+,28+,29-,31?/m1/s1
|
|||||
| InChIKey |
OZTKUJWVDOXHCQ-QINHOXNVSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
773.771
|
Polar area
|
279.07
|
||
|
Complexity
|
1578.381649
|
xlogp Value
|
-2.3344
|
|||
|
Heavy Count
|
53
|
Rot Bonds
|
22
|
|||
|
Hbond acc
|
18
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker