Linker Information
General Information of This Linker
| Linker ID |
LIN0MHGLI
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| Linker Name |
Aminobenzazepine-linker Formula II-4
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C61H108F4O28
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| Isosmiles |
FC1=C(OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(C)=O)=O)C(F)=C(F)C=C1F
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| InChI |
InChI=1S/C61H108F4O28/c1-55(66)2-4-68-6-8-70-10-12-72-14-16-74-18-20-76-22-24-78-26-28-80-30-32-82-34-36-84-38-40-86-42-44-88-46-48-90-50-52-92-53-51-91-49-47-89-45-43-87-41-39-85-37-35-83-33-31-81-29-27-79-25-23-77-21-19-75-17-15-73-13-11-71-9-7-69-5-3-58(67)93-61-59(64)56(62)54-57(63)60(61)65/h54H,2-53H2,1H3
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| InChIKey |
WQVJKBVLEUIWRL-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1365.499
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Polar area
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274.12
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Complexity
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1614.550279
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xlogp Value
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2.9326
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Heavy Count
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93
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Rot Bonds
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79
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Hbond acc
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28
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Hbond Donor
|
0
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||