Linker Information
General Information of This Linker
| Linker ID |
LIN0MGVII
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| Linker Name |
Aminobenzazepine-linker Formula II-22
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C39H63F4NO21S
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| Isosmiles |
FC1=CC(F)=C(F)C(OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CS(=O)(O)=O)C(O)=O)=O)=O)=C1F
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| InChI |
InChI=1S/C39H63F4NO21S/c40-31-29-32(41)37(43)38(36(31)42)65-35(46)2-4-53-6-8-55-10-12-57-14-16-59-18-20-61-22-24-63-26-28-64-27-25-62-23-21-60-19-17-58-15-13-56-11-9-54-7-5-52-3-1-34(45)44-33(39(47)48)30-66(49,50)51/h29,33H,1-28,30H2,(H,44,45)(H,47,48)(H,49,50,51)/t33-/m0/s1
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| InChIKey |
WZLXDQOPCMPMPS-XIFFEERXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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989.978
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Polar area
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267.06
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Complexity
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1418.607989
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xlogp Value
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0.6016
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Heavy Count
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66
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Rot Bonds
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47
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Hbond acc
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19
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-17 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||