Linker Information
General Information of This Linker
| Linker ID |
LIN0MFUEP
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| Linker Name |
TW202506738A-C-217-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C71H114N14O40
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| Isosmiles |
COCCOCOCOCOCOCOCOCOCC(NCCCC[C@H](NC(CCCNC([C@@H](N1C(C=CC1=O)=O)[C@H](N2C(C=CC2=O)=O)C(NCCCC(N[C@@H](CCCCNC(COCOCOCOCOCOCOCOCCOC)=O)C(NCC(NCC(NCOCC(O)=O)=O)=O)=O)=O)=O)=O)=O)C(NCC(NCC(NCOC(C)C(O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C71H114N14O40/c1-49(71(104)105)125-34-81-57(91)27-77-55(89)29-79-68(101)51(11-5-7-19-73-59(93)31-112-38-116-42-120-46-124-48-122-44-118-40-114-36-109-25-23-107-3)83-53(87)13-9-21-75-70(103)66(85-62(96)16-17-63(85)97)65(84-60(94)14-15-61(84)95)69(102)74-20-8-12-52(86)82-50(67(100)78-28-54(88)76-26-56(90)80-33-110-32-64(98)99)10-4-6-18-72-58(92)30-111-37-115-41-119-45-123-47-121-43-117-39-113-35-108-24-22-106-2/h14-17,49-51,65-66H,4-13,18-48H2,1-3H3,(H,72,92)(H,73,93)(H,74,102)(H,75,103)(H,76,88)(H,77,89)(H,78,100)(H,79,101)(H,80,90)(H,81,91)(H,82,86)(H,83,87)(H,98,99)(H,104,105)/t49?,50-,51-,65-,66-/m0/s1
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| InChIKey |
PNRGEAMOFIBUDY-HEJHNYQESA-N
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| Pharmaceutical Properties |
Molecule Weight
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1803.751
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Polar area
|
683.16
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Complexity
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.
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xlogp Value
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-8.9245
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Heavy Count
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125
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Rot Bonds
|
81
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Hbond acc
|
38
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker