Linker Information
General Information of This Linker
| Linker ID |
LIN0MDQYJ
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| Linker Name |
Aminobenzazepine-linker Formula II-3
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C29H46F4O12
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| Isosmiles |
CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O
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| InChI |
InChI=1S/C29H46F4O12/c1-2-35-5-6-37-9-10-39-13-14-41-17-18-43-21-22-44-20-19-42-16-15-40-12-11-38-8-7-36-4-3-26(34)45-29-27(32)24(30)23-25(31)28(29)33/h23H,2-22H2,1H3
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| InChIKey |
GQDYDZKKEWJMCJ-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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662.667
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Polar area
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118.6
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Complexity
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787.567483
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xlogp Value
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2.7244
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Heavy Count
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45
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Rot Bonds
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32
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Hbond acc
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12
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Hbond Donor
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0
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
14.8 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||