Linker Information
General Information of This Linker
| Linker ID |
LIN0LXFAB
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|---|---|---|---|---|---|---|
| Linker Name |
MC-Ala-Ala-RG-1
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C33H40N6O9
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| Isosmiles |
O=C(N[C@@H](C)C(NC1=CC=C(COC(NCC2=CC=CC=C2N(C)C(O)=O)=O)C=C1)=O)[C@H](C)NC(CCCCCN3C(C=CC3=O)=O)=O
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| InChI |
InChI=1S/C33H40N6O9/c1-21(35-27(40)11-5-4-8-18-39-28(41)16-17-29(39)42)30(43)36-22(2)31(44)37-25-14-12-23(13-15-25)20-48-32(45)34-19-24-9-6-7-10-26(24)38(3)33(46)47/h6-7,9-10,12-17,21-22H,4-5,8,11,18-20H2,1-3H3,(H,34,45)(H,35,40)(H,36,43)(H,37,44)(H,46,47)/t21-,22-/m0/s1
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| InChIKey |
TZIJCAORKKHUDC-VXKWHMMOSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
664.716
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Polar area
|
203.55
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Complexity
|
1466.687811
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xlogp Value
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2.6605
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Heavy Count
|
48
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Rot Bonds
|
16
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Hbond acc
|
8
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker