Linker Information
General Information of This Linker
| Linker ID |
LIN0LWEQR
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|---|---|---|---|---|---|---|
| Linker Name |
WO2023173026A1-ADC-L078-171-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C48H65N9O13S3
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N=C(C(CS)=N2)CS)C2=C1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(COC(N(CC4=CC=CS4)CC(O)=O)=O)C=C3)=O)=O)C
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| InChI |
InChI=1S/C48H65N9O13S3/c1-31(2)43(56-41(58)13-16-66-18-20-68-22-23-69-21-19-67-17-15-50-44(61)33-9-12-36-38(25-33)54-40(30-72)39(29-71)53-36)46(63)55-37(6-3-14-51-47(49)64)45(62)52-34-10-7-32(8-11-34)28-70-48(65)57(27-42(59)60)26-35-5-4-24-73-35/h4-5,7-12,24-25,31,37,43,71-72H,3,6,13-23,26-30H2,1-2H3,(H,50,61)(H,52,62)(H,55,63)(H,56,58)(H,59,60)(H3,49,51,64)/t37-,43-/m0/s1
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| InChIKey |
MJCPIHJJMLIEKL-VCRWUWJOSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1072.299
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Polar area
|
301.06
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Complexity
|
2296.665955
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xlogp Value
|
3.6734
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Heavy Count
|
73
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Rot Bonds
|
34
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Hbond acc
|
17
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker