Linker Information
General Information of This Linker
| Linker ID |
LIN0LVUGB
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
TW202506738A-C-214-LINKER
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C76H123N13O38
|
|||||
| Isosmiles |
COCCOCOCOCOCOCOCOCOCC(NCCCC[C@H](NC(CCCNC([C@@H](N1C(C=CC1=O)=O)[C@H](N2C(C=CC2=O)=O)C(NCCCC(N[C@@H](CCCCCC(COCCOCCOCCOCCOCCOCCOCCOCCOC)=O)C(NCC(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)C(NCC(NCC(NCC(O)=O)=O)=O)=O)=O
|
|||||
| InChI |
InChI=1S/C76H123N13O38/c1-110-22-24-112-26-27-113-28-29-114-30-31-115-32-33-116-34-35-117-36-37-118-38-39-119-46-55(90)10-4-3-5-11-56(73(106)84-42-62(95)80-40-60(93)82-44-69(102)103)86-58(91)13-8-20-78-75(108)71(88-65(98)15-16-66(88)99)72(89-67(100)17-18-68(89)101)76(109)79-21-9-14-59(92)87-57(74(107)85-43-63(96)81-41-61(94)83-45-70(104)105)12-6-7-19-77-64(97)47-121-49-123-51-125-53-127-54-126-52-124-50-122-48-120-25-23-111-2/h15-18,56-57,71-72H,3-14,19-54H2,1-2H3,(H,77,97)(H,78,108)(H,79,109)(H,80,95)(H,81,96)(H,82,93)(H,83,94)(H,84,106)(H,85,107)(H,86,91)(H,87,92)(H,102,103)(H,104,105)/t56-,57-,71-,72-/m0/s1
|
|||||
| InChIKey |
DUUVCMGXGAIPGS-QAQMXBEMSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1826.873
|
Polar area
|
652.67
|
||
|
Complexity
|
.
|
xlogp Value
|
-7.7306
|
|||
|
Heavy Count
|
127
|
Rot Bonds
|
85
|
|||
|
Hbond acc
|
36
|
Hbond Donor
|
13
|
|||
Each Antibody-drug Conjugate Related to This Linker