Linker Information
General Information of This Linker
| Linker ID |
LIN0LUPJF
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| Linker Name |
US20230285580A1 B12-B6 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C41H67N5O14
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| Isosmiles |
C[C@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)CNC2=CC=C(CO)C=C2
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| InChI |
InChI=1S/C41H67N5O14/c1-32(2)40(41(52)44-33(3)30-43-35-6-4-34(31-47)5-7-35)45-37(49)11-14-53-16-18-55-20-22-57-24-26-59-28-29-60-27-25-58-23-21-56-19-17-54-15-12-42-36(48)10-13-46-38(50)8-9-39(46)51/h4-9,32-33,40,43,47H,10-31H2,1-3H3,(H,42,48)(H,44,52)(H,45,49)/t33-,40-/m0/s1
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| InChIKey |
GMBNPKDVRGFTKS-QQLMSYFVSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
854.008
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Polar area
|
230.78
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Complexity
|
1295.985459
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xlogp Value
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0.1905
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Heavy Count
|
60
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Rot Bonds
|
38
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Hbond acc
|
15
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker