Linker Information
General Information of This Linker
| Linker ID |
LIN0LRWNK
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|---|---|---|---|---|---|---|
| Linker Name |
LT4212552T-ADC-36-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C23H27N5O8
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCCN2C(C=CC2=O)=O)=O
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| InChI |
InChI=1S/C23H27N5O8/c29-17(7-4-10-28-20(32)8-9-21(28)33)24-12-18(30)25-13-19(31)27-16(23(36)26-14-22(34)35)11-15-5-2-1-3-6-15/h1-3,5-6,8-9,16H,4,7,10-14H2,(H,24,29)(H,25,30)(H,26,36)(H,27,31)(H,34,35)/t16-/m0/s1
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| InChIKey |
HPWXBRUMVRFNBW-INIZCTEOSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
501.496
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Polar area
|
191.08
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Complexity
|
975.7337252
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xlogp Value
|
-2.1477
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Heavy Count
|
36
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Rot Bonds
|
14
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Hbond acc
|
7
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker