Linker Information

General Information of This Linker
Linker ID
LIN0LQUFZ
Linker Name
Glutaricacid-peptide-based linker
Linker Type
Flexible reactive (amino) linker
Antibody-Linker Relation
Cleavable
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TWEAKR-KSPi-ADC1 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 80.00% (Day 17) Positive CTLA4 expression (CTLA4 +++/++)
Method Description
To exclude anti-tumor effects based on the agonistic activity of the anti-TWEAKR antibody, a maximum dose of 5 mg/kg biweekly was chosen for investigating the anti-tumor activity of TWEAKR-KSPi-ADC1 in mice bearing CT26 tumors.
In Vivo Model CT26 CDX model
In Vitro Model Colon carcinoma CT26 cells CVCL_7254
References
Ref 1 Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties. Oncoimmunology. 2022 Feb 9;11(1):2037216. doi: 10.1080/2162402X.2022.2037216.

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