Linker Information
General Information of This Linker
| Linker ID |
LIN0LPISQ
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| Linker Name |
DIBAC-PEG4-GGFG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C45H54N6O12
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| Isosmiles |
OC(CNC([C@@H](NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N1C2=C(C#CC(C=CC=C3)=C3C1)C=CC=C2)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O
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| InChI |
InChI=1S/C45H54N6O12/c52-39(16-17-43(56)51-32-36-12-5-4-10-34(36)14-15-35-11-6-7-13-38(35)51)46-19-21-61-23-25-63-27-26-62-24-22-60-20-18-40(53)47-29-41(54)48-30-42(55)50-37(45(59)49-31-44(57)58)28-33-8-2-1-3-9-33/h1-13,37H,16-32H2,(H,46,52)(H,47,53)(H,48,54)(H,49,59)(H,50,55)(H,57,58)/t37-/m0/s1
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| InChIKey |
NLAQYNJWFVJVOU-QNGWXLTQSA-N
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| Pharmaceutical Properties |
Molecule Weight
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870.957
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Polar area
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240.03
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Complexity
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1983.366
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xlogp Value
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0.4466
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Heavy Count
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63
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Rot Bonds
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28
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Hbond acc
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11
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP7 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.036 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 13% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||