Linker Information
General Information of This Linker
| Linker ID |
LIN0LOJWL
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
WO2023173026A1-ADC-L078-118-Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C41H58N8O12S2
|
|||||
| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N=C(C(CS)=N2)CS)C2=C1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(COC(O)=O)C=C3)=O)=O)C
|
|||||
| InChI |
InChI=1S/C41H58N8O12S2/c1-26(2)36(39(53)48-31(4-3-12-44-40(42)54)38(52)45-29-8-5-27(6-9-29)23-61-41(55)56)49-35(50)11-14-57-16-18-59-20-21-60-19-17-58-15-13-43-37(51)28-7-10-30-32(22-28)47-34(25-63)33(24-62)46-30/h5-10,22,26,31,36,62-63H,3-4,11-21,23-25H2,1-2H3,(H,43,51)(H,45,52)(H,48,53)(H,49,50)(H,55,56)(H3,42,44,54)/t31-,36-/m0/s1
|
|||||
| InChIKey |
ZCOREGQGHAYUHQ-NWWLCHBLSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
919.093
|
Polar area
|
280.75
|
||
|
Complexity
|
1855.617617
|
xlogp Value
|
2.5831
|
|||
|
Heavy Count
|
63
|
Rot Bonds
|
30
|
|||
|
Hbond acc
|
15
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker