Linker Information
General Information of This Linker (ID: LIN0LHYMY)
| Name |
MC-DVA-PABC
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Isosmiles |
O=C(N[C@H](C)C(NC1=CC=C(CO)C=C1)=O)[C@@H](C(C)C)NC([C@@H](CC(O)=O)NC(CCCCCN2C(C=CC2=O)=O)=O)=O
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Dara-DVA-I030 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.142 nM
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| In Vitro Model | Plasma cell myeloma | NCI-H929 cells | CVCL_1600 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.385 nM
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| In Vitro Model | Plasma cell myeloma, Multiple myeloma | MM.1S cells | CVCL_8792 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10 nM | |||
| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
Belan-DVA-I030 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.237 nM
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| In Vitro Model | Plasma cell myeloma | NCI-H929 cells | CVCL_1600 | ||
References