Linker Information
General Information of This Linker
| Linker ID |
LIN0LGYZM
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|---|---|---|---|---|---|---|
| Linker Name |
H1H21234N-N297Q- LP5 lINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C103H163N15O45
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| Isosmiles |
NCCOCCOCCCCCN(N=N1)C(C2=C(C3)C=CC=C2)=C1C4=C(N3C(CCC(NCCOCCOCCOCCOCCC(N[C@H](CCCCNC(COC5CCCCCC6=C5N=NN6C[C@@H]7O[C@@H](C)[C@@H](O)C(O)C7O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)=O)=O)=O)=O)C=CC=C4.OC[C@H]8[C@H](O[C@H](O9)[C@@H](O)[C@H](O)[C@@H](O[C@@H]%10[C@H](O)C(O)[C@H](O[C@@H](O%11)[C@H](O)[C@H](O)[C@H](O[C@@H]%12[C@H](O)C([C@H](O)[C@H](O%12)CO)O)[C@H]%11CO)[C@H](O%10)CO)[C@@H]9CO)[C@@H](O)[C@H](O%13)[C@H]%13O8
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| InChI |
InChI=1S/C73H113N15O20.C30H50O25/c1-48(2)63(71(97)80-54(72(98)99)21-16-30-78-73(75)100)81-70(96)53(20-12-13-29-76-61(91)47-107-57-24-7-4-6-23-56-65(57)83-85-88(56)46-58-68(94)69(95)67(93)49(3)108-58)79-60(90)27-34-102-38-41-105-43-44-106-42-40-104-36-31-77-59(89)25-26-62(92)86-45-50-17-8-9-18-51(50)66-64(52-19-10-11-22-55(52)86)82-84-87(66)32-14-5-15-33-101-37-39-103-35-28-74;31-1-6-11(36)12(37)16(41)26(46-6)51-21-7(2-32)47-27(17(42)13(21)38)52-22-8(3-33)48-28(18(43)14(22)39)53-23-9(4-34)49-29(19(44)15(23)40)54-24-10(5-35)50-30-25(55-30)20(24)45/h8-11,17-19,22,48-49,53-54,57-58,63,67-69,93-95H,4-7,12-16,20-21,23-47,74H2,1-3H3,(H,76,91)(H,77,89)(H,79,90)(H,80,97)(H,81,96)(H,98,99)(H3,75,78,100);6-45H,1-5H2/t49-,53+,54-,57?,58-,63-,67+,68?,69?;6-,7-,8-,9+,10+,11-,12?,13+,14?,15+,16-,17-,18-,19+,20-,21-,22-,23+,24+,25+,26-,27-,28-,29+,30+/m01/s1
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| InChIKey |
AVKDIUOSZMFZSL-ZXTCOZRKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2331.497
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Polar area
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879.25
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Complexity
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.
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xlogp Value
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-9.6393
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Heavy Count
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163
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Rot Bonds
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63
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Hbond acc
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51
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Hbond Donor
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27
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1H21234N-N297Q-LP5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.2 nM
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Positive MSR1 expression (MSR1+++/++) | ||
| Method Description |
Anti-MSR1-LXR Agonist Conjugate Activity in Differentiated THP-3/LXR-Luc cells
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| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP-1/LXR-Luc cells | CVCL_5115 | ||
References