Linker Information

General Information of This Linker
Linker ID
LIN0LGIYJ
Linker Name
Psyche-Ax
Linker Type
Photo-sensitive linker
Antibody-Linker Relation
Uncleavable
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
ZHER2:342-Cupid-His-Ax-SiPc [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
82.40% (Day 21)
Low HER2 expression (HER2+)
Method Description
The Kadcyla (the anti- Her2 ADC) group were administered at 300 g.
In Vivo Model KPL- 4 cell line xenograft model
In Vitro Model Breast inflammatory carcinoma KPL-4 cells CVCL_5310
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
93.40% (Day 21)
Low HER2 expression (HER2+)
Method Description
The ZHER2:342-Cupid-His-Ax-SiPc group were administered at 150 g.
In Vivo Model KPL- 4 cell line xenograft model
In Vitro Model Breast inflammatory carcinoma KPL-4 cells CVCL_5310
References
Ref 1 Pathological complete remission of relapsed tumor by photo-activating antibody-mimetic drug conjugate treatment. Cancer Sci. 2022 Dec;113(12):4350-4362.

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