Linker Information
General Information of This Linker
| Linker ID |
LIN0LEIDY
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|---|---|---|---|---|---|---|
| Linker Name |
AU2023279443A1, Example A12, Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H72N10O23P2
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| Isosmiles |
CC([C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COP(O)(O)=O)=O)=O)NC([C@H](CC(N[C@H]2CCOC2=O)=O)NC(CCOCCOCCOCCOCCNC([C@H](CNC(CCP(O)(O)=O)=O)N3C(C=CC3=O)=O)=O)=O)=O)C
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| InChI |
InChI=1S/C47H72N10O23P2/c1-29(2)41(45(66)55-32(4-3-14-50-47(48)68)42(63)52-31-7-5-30(6-8-31)28-80-82(72,73)74)56-43(64)34(26-38(60)53-33-11-17-79-46(33)67)54-37(59)12-16-75-19-21-77-23-24-78-22-20-76-18-15-49-44(65)35(57-39(61)9-10-40(57)62)27-51-36(58)13-25-81(69,70)71/h5-10,29,32-35,41H,3-4,11-28H2,1-2H3,(H,49,65)(H,51,58)(H,52,63)(H,53,60)(H,54,59)(H,55,66)(H,56,64)(H3,48,50,68)(H2,69,70,71)(H2,72,73,74)/t32-,33-,34-,35-,41-/m0/s1
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| InChIKey |
PKXCJBPGTKHCGE-KRLSWSLDSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1207.088
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Polar area
|
483.71
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Complexity
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2354.031757
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xlogp Value
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-3.8346
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Heavy Count
|
82
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Rot Bonds
|
40
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Hbond acc
|
19
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker