Linker Information
General Information of This Linker
| Linker ID |
LIN0LCPJS
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|---|---|---|---|---|---|---|
| Linker Name |
WO2023173026A1-ADC-L078-173-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C48H66N10O13S2
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| Isosmiles |
CC([C@H](NC(CCOCCOCCOCCOCCNC(C1=CC=C(N=C(C(CS)=N2)CS)C2=C1)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(COC(N(CC4=CC=CN4)CC(O)=O)=O)C=C3)=O)=O)C
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| InChI |
InChI=1S/C48H66N10O13S2/c1-31(2)43(57-41(59)13-17-67-19-21-69-23-24-70-22-20-68-18-16-51-44(62)33-9-12-36-38(25-33)55-40(30-73)39(29-72)54-36)46(64)56-37(6-4-15-52-47(49)65)45(63)53-34-10-7-32(8-11-34)28-71-48(66)58(27-42(60)61)26-35-5-3-14-50-35/h3,5,7-12,14,25,31,37,43,50,72-73H,4,6,13,15-24,26-30H2,1-2H3,(H,51,62)(H,53,63)(H,56,64)(H,57,59)(H,60,61)(H3,49,52,65)/t37-,43-/m0/s1
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| InChIKey |
UZUAABRYJUNPEF-VCRWUWJOSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1055.247
|
Polar area
|
316.85
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Complexity
|
2296.665955
|
xlogp Value
|
2.94
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Heavy Count
|
73
|
Rot Bonds
|
34
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Hbond acc
|
16
|
Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker