Linker Information
General Information of This Linker
| Linker ID |
LIN0KZOGI
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|---|---|---|---|---|---|---|
| Linker Name |
Mepstra-PD-PEG3-Mal-Cit-PABC
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| Linker Type |
Flexible dual-reactive (thiol) linker; Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C52H78Br2N12O15
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| Isosmiles |
CC(C)C(NC(=O)CCOCCOCCOCCn1nnc2c1CCC1C(CC2)C1COC(=O)NCCOCCOCCNC(=O)CCn1c(=O)c(Br)c(Br)c(=O)n1C)C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C52H78Br2N12O15/c1-33(2)46(48(71)60-40(5-4-16-57-51(55)74)47(70)59-35-8-6-34(31-67)7-9-35)61-43(69)15-21-76-25-29-80-30-28-79-24-20-65-41-13-11-37-36(10-12-39(41)62-63-65)38(37)32-81-52(75)58-18-23-78-27-26-77-22-17-56-42(68)14-19-66-50(73)45(54)44(53)49(72)64(66)3/h6-9,33,36-38,40,46,67H,4-5,10-32H2,1-3H3,(H,56,68)(H,58,75)(H,59,70)(H,60,71)(H,61,69)(H3,55,57,74)
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| InChIKey |
NRTYWYSFLOAVLN-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1271.073
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Polar area
|
350.94
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Complexity
|
81
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xlogp Value
|
1.0154
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Heavy Count
|
81
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Rot Bonds
|
37
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Hbond acc
|
20
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker
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