Linker Information
General Information of This Linker
| Linker ID |
LIN0KYFFH
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| Linker Name |
COT-PEG4-branch-PEG2-EvcPAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C88H136N16O33
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| Isosmiles |
O=C(NCCOCCOCCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC(O)=O)=O)=O)=O)CCC(O)=O)=O)CCOCC(NC(CCOCCOCCNC(COC2CCCCCC#C2)=O)=O)COCCC(NCCOCCOCCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(O)=O)=O)=O)=O)CCC(O)=O)=O)=O
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| InChI |
InChI=1S/C88H136N16O33/c1-57(2)77(83(119)101-65(14-10-33-94-85(89)121)79(115)97-61-20-16-59(17-21-61)52-136-87(123)124)103-81(117)67(24-26-75(111)112)99-72(108)31-39-128-47-49-130-43-35-91-69(105)28-41-133-54-63(96-71(107)30-38-127-46-51-132-45-37-93-74(110)56-135-64-12-8-6-5-7-9-13-64)55-134-42-29-70(106)92-36-44-131-50-48-129-40-32-73(109)100-68(25-27-76(113)114)82(118)104-78(58(3)4)84(120)102-66(15-11-34-95-86(90)122)80(116)98-62-22-18-60(19-23-62)53-137-88(125)126/h16-23,57-58,63-68,77-78H,5-8,10-12,14-15,24-56H2,1-4H3,(H,91,105)(H,92,106)(H,93,110)(H,96,107)(H,97,115)(H,98,116)(H,99,108)(H,100,109)(H,101,119)(H,102,120)(H,103,117)(H,104,118)(H,111,112)(H,113,114)(H,123,124)(H,125,126)(H3,89,94,121)(H3,90,95,122)/t64?,65-,66-,67-,68-,77-,78-/m0/s1
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| InChIKey |
AFPLBYRVNJXONS-WHSVDXGNSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1946.135
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Polar area
|
710.17
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Complexity
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.
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xlogp Value
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-0.2302
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Heavy Count
|
137
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Rot Bonds
|
75
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Hbond acc
|
29
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Hbond Donor
|
20
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Each Antibody-drug Conjugate Related to This Linker