Linker Information
General Information of This Linker
| Linker ID |
LIN0KWONA
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| Linker Name |
PSMA-HC41-LD64 LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C45H66N8O13
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| Isosmiles |
CN(C(OCC1=CC=C(OC(N(CCOCCO)CCN(C)C(OCC2=CC=C(NC([C@H](C)NC([C@@H](N(C)C)C(C)C)=O)=O)C=C2)=O)=O)C=C1)=O)CCNCCOCCN3C(C=CC3=O)=O
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| InChI |
InChI=1S/C45H66N8O13/c1-32(2)40(49(4)5)42(58)47-33(3)41(57)48-36-12-8-34(9-13-36)30-65-44(60)51(7)21-22-52(23-27-63-29-25-54)45(61)66-37-14-10-35(11-15-37)31-64-43(59)50(6)20-18-46-19-26-62-28-24-53-38(55)16-17-39(53)56/h8-17,32-33,40,46,54H,18-31H2,1-7H3,(H,47,58)(H,48,57)/t33-,40-/m0/s1
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| InChIKey |
WSLGCUUDZUDYPZ-QQLMSYFVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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927.066
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Polar area
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238.16
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Complexity
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1807.582843
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xlogp Value
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1.8939
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Heavy Count
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66
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Rot Bonds
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28
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Hbond acc
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15
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
PSMA-HC41-LD64 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
2.07 nM
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Positive PSMA expression (PSMA +++/++) | ||
| Method Description |
In vitro cytotoxicity of anti-PSMA ADCs in human tumour cells expressing PSMAPSMA-positive cell line LNCaP-C4.2
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| In Vitro Model | Prostate carcinoma | LNCaP-C4.2 cells | CVCL_4782 | ||