Linker Information
General Information of This Linker
| Linker ID |
LIN0KUONN
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| Linker Name |
L11 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C185H335N17O84S
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| Isosmiles |
CC([C@H](NC(CCOCCOCCNS(=O)(NC(OCCN(CCOCCOCCOCCC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C(CN(C)C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)=C1)O)=O)=O)C(C)C)=O)C(CCOCCNC(CCOCCOCCOCCOCCN2C(C=CC2=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(O)C(CN(C)C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)=C3)=O)=O)C
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| InChI |
InChI=1S/C185H335N17O84S/c1-157(2)177(181(219)194-163(9-7-25-189-183(186)221)179(217)192-161-11-13-165(203)159(153-161)155-199(5)170(208)20-35-230-48-57-239-64-69-244-73-77-248-81-85-252-89-93-256-97-101-260-105-109-264-113-117-268-121-125-272-129-133-276-137-141-280-145-149-284-151-147-282-143-139-278-135-131-274-127-123-270-119-115-266-111-107-262-103-99-258-95-91-254-87-83-250-79-75-246-71-66-241-59-50-232-38-23-175(213)214)196-168(206)18-33-228-45-52-234-41-28-191-287(224,225)198-185(223)286-44-30-201(172(210)22-37-226-40-27-188-167(205)17-32-227-46-55-238-63-68-243-62-54-236-43-31-202-173(211)15-16-174(202)212)29-42-235-53-61-237-56-47-229-34-19-169(207)197-178(158(3)4)182(220)195-164(10-8-26-190-184(187)222)180(218)193-162-12-14-166(204)160(154-162)156-200(6)171(209)21-36-231-49-58-240-65-70-245-74-78-249-82-86-253-90-94-257-98-102-261-106-110-265-114-118-269-122-126-273-130-134-277-138-142-281-146-150-285-152-148-283-144-140-279-136-132-275-128-124-271-120-116-267-112-108-263-104-100-259-96-92-255-88-84-251-80-76-247-72-67-242-60-51-233-39-24-176(215)216/h11-16,153-154,157-158,163-164,177-178,191,203-204H,7-10,17-152,155-156H2,1-6H3,(H,188,205)(H,192,217)(H,193,218)(H,194,219)(H,195,220)(H,196,206)(H,197,207)(H,198,223)(H,213,214)(H,215,216)(H3,186,189,221)(H3,187,190,222)/t163-,164-,177-,178-/m0/s1
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| InChIKey |
RSLDZMZUJKNKSJ-NJJBXJHFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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4173.817
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Polar area
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1165.61
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Complexity
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.
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xlogp Value
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-1.5436
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Heavy Count
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287
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Rot Bonds
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227
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Hbond acc
|
82
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Hbond Donor
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17
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CD74 Milatuzumab DANAPAE152C S375C-P1-L11-P1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.42 nM
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High CD74 expression (CD74 +++) | ||
| Method Description |
CD74 Milatuzumab DANAPAE152C S375C-P1-L11-P1 was tested in EOL-1
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||