Linker Information
General Information of This Linker
| Linker ID |
LIN0KSPIT
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|---|---|---|---|---|---|---|
| Linker Name |
CN119326907A Trastuzumab-GDP-N-P1/P1-P1-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C60H84N16O23
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCOCC2=CN(N=N2)CCOCCN(C(CCC(NC[C@H](O3)[C@@H](O)[C@@H](O)[C@H](O)[C@H]3O)=O)=O)CCOCCN(N=N4)C=C4COCCC(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(NCC(O)=O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C60H84N16O23/c77-45(61-27-44-55(89)56(90)57(91)60(94)99-44)11-12-52(84)74(15-21-95-23-17-75-34-40(70-72-75)36-97-19-13-46(78)62-28-48(80)64-30-50(82)68-42(58(92)66-32-53(85)86)25-38-7-3-1-4-8-38)16-22-96-24-18-76-35-41(71-73-76)37-98-20-14-47(79)63-29-49(81)65-31-51(83)69-43(59(93)67-33-54(87)88)26-39-9-5-2-6-10-39/h1-10,34-35,42-44,55-57,60,89-91,94H,11-33,36-37H2,(H,61,77)(H,62,78)(H,63,79)(H,64,80)(H,65,81)(H,66,92)(H,67,93)(H,68,82)(H,69,83)(H,85,86)(H,87,88)/t42-,43-,44-,55+,56+,57-,60-/m0/s1
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| InChIKey |
PTVAWVRJZYOKSE-ZJHRSDIKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1397.421
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Polar area
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545.3
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Complexity
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2942.705835
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xlogp Value
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-7.7373
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Heavy Count
|
99
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Rot Bonds
|
47
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Hbond acc
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27
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Hbond Donor
|
15
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Each Antibody-drug Conjugate Related to This Linker